Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. matrix tablets by using Eudragit RSPO and natural gums like guar copal as rate The use of synthetic Eudragit RSPO and gum copal were unable to retard the. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.
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Various formulation and process variables such as amount of polymer, concentration of surfactant, amount of drug, stirring speed, stirring time, and temperature play a key role in determining the final physical and mechanical characteristics of nanoparticles.
On the basis of the results obtained from solubility study, SDS was chosen as surfactant to stabilize nanoparticles and acetone was chosen as an organic phase. This can be due to the fact that an increase in polymer concentration led to an enhancement of the concentration gradient between emulsion droplets and the continuous phase, as a result increasing the amount of drug partitioning into the continuous phase [ 38 ].
Methacrylic resins Eudragit appear particularly attractive due to their high chemical stability and compactility properties, and many literatures substantiate use in the development of control release matrix tablet [ 1213 ]. Tenofovir was encapsulated in Eudragit RS PO in this study intended for oral administration since most studies are based on the prevention of HIV transmission [ 13 ]. Figure 5 in vitro cumulative release of metformin. Introduction Tenofovir is one of the first-line drugs used in the treatment of the human immunodeficiency virus HIV infected adults.
Figure 4 in vitro cumulative release of metformin. It was applied to determine the significance and the magnitude of the effects of the main variable and their interactions by applying probability value value.
The percentage prediction error was calculated which helps in the validation of generated regression by using 8.
Time-controlled Drug release
It was observed that ratio of a polymer to a drug has significant effect whereas other factors do not have an effect on EE. Concentration of drug released was determined using UV spectrophotometer. It also does not contain any points at the corners, which helps to avoid unreasonable results [ 16 ].
For such drugs it becomes essential to include hydrophobic polymers in the matrix system [ 15 ].
Journal of Nanomaterials
Factors with values that are less than 0. Tenofovir is one of the first-line drugs used in the treatment of the human immunodeficiency virus HIV infected adults. An identical release profiles were observed in both dissolution media, which is due to the eudeagit that Eudragit RS PO is pH independent; the release of drug is dependent on the diffusion of the drug from the matrix of the polymer.
Eudragit RSPO contains quaternary ammonium groups, and solubilization of these quaternary ammonium groups in acidic pH leads to formation of pores in the matrix, thereby releasing metformin HCl in the acidic pH.
Evonik EUDRAGIT® RS PO Copolymer
View at Google Scholar M. Eurdagit may be due to the reason that the gums in higher concentrations in the tablets might have produced dense matrix around the drug eudrgait, providing more barriers for them to escape and dissolve. However, the release of a drug in acidic media pH 1. However, the mixtures were continued to be sonicated at different time frames and were left to stir overnight to aid size reduction and to evaporate solvent present.
Therefore, to maintain the oral delivery route, formulating the drug into polymeric nanoparticles is essential for improving the bioavailability. This phenomenon may be attributed to surface erosion or initial disaggregation of the matrix tablet prior to gel layer formation around the tablet core [ 25 ].
Just before compression, the surfaces of the die and punches were lubricated with magnesium stearate. Angle of repose was determined by funnel method.
Figure 3 in vitro cumulative release of metformin. College of Pharmacy, Kamptee, Nagpur, India for providing necessary facilities to carry out this work.
Eudragit RSPO | Gum Copal | Gum Damar | Matrix Tablets | Release Kinetics
Further, such dense matrix, specifically when it is hydrophobic in nature, may be expected to favor less penetration of the dissolution medium in the tablets. Hausner’s values of the prepared granules ranged from 1.
It is insoluble at the physiological pH but the cationic charge eduragit rapid permeation through the intestinal mucosa [ 10 ]. To graphically demonstrate the influence of each factor on the response, the surface plots for each response were generated results using BBD [ 23 ]. The objective of present study was to develop an optimized polymeric nanoparticle system uedragit the antiretroviral drug tenofovir.
In each formulation, the amount of the active ingredient is mg and the total weight of a tablet is mg. The samples were prepared using a double adhesive tape stuck to an aluminium stub. It is a potent inhibitor of the virus nucleotide reverse transcriptase and was approved for clinical use in [ 1 ].
The in vitro drug release studies were carried out in dissolution media pH 7. The dissolution test was performed in triplicate.
They were then coated with gold under an argon atmosphere using a gold sputter in a high vacuum evaporator. Kakde 1 and M. Mumbai, Indiaand gum copal and euragit damar were received as a gift sample from Imex Inc.
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