Kidney Stones >; Tamsulosin Ineffective for Small Ureteral Stones In the double-blind STONE (Study of Tamsulosin for Urolithiasis in the. Nephrolithiasis specifically refers to calculi in the kidneys, but renal selective blockers, such as tamsulosin, also relax the musculature of the. Medscape – Benign prostatic hyperplasia-specific dosing for Flomax (tamsulosin), frequency-based adverse effects, comprehensive interactions.

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Time limit is exhausted. InKubacz and Catchpole 15 compared the effectiveness of treating ureteral colic with fpomax, phentolamine, and propanolol. An Update – R. Alpha Blockers in Renal Colic: In a prospective randomized study, tamsulosin was compared with terazosin and doxazosin.

Now, though, we have better evidence to guide our decisions. Please review our privacy policy.

Surgical management of urinary lithiasis. At the nephrolifhiasis of the 4-week study, all patients were assessed for stone-free status and filled out the validated Ureteral Stent Nephrolithiadis Questionnaire USSQ.

Int J Urology Our findings do not support the use of tamsulosin for symptomatic urinary stones smaller than 9 mm. By registering you consent to the collection and use of your information to provide the products and services you have requested from us and as described in our privacy policy and terms and conditions.

Tamsulosin Ineffective for Small Ureteral Stones – Renal and Urology News

For over a decade, calcium channel blockers i. Stone size, location, and passage were confirmed by computed tomography. Medical Expulsion Therapy in Ureteral Colic: The group did find a significant difference in passage rate but the flaws above are important to note.

Simplifying Mechanical Ventilation — Nephrolitbiasis I: AlphaBlockers and Ureteral Stents Ureteral stents are often used in the treatment of renal and ureteral stones. Medical expulsive therapy using the alpha blocker tamsulosin does not aid passage of ureteral stones less than 9 mm in diameter, according to study findings published online in JAMA Internal Medicine. Asks a clinically important, patient centered question Multicenter study Largest RCT to date on this topic Randomization nephrolituiasis blinding appropriately performed Study was well protected against the risk of bias i.


Role of adjunctive medical therapy with nifedipine and deflazacort after extracorporeal shock wave lithotripsy of ureteral stones. Alpha-1 receptors are located in the human ureter, especially the distal ureter. Mean stone size was small 3. InBorghi and colleagues demonstrated the efficacy of the calcium channel blocker nifedipine in the treatment of ureteral stones in a randomized, double-blind, placebo-controlled study.

Applicability to our patients in the ED is unclear. Medical therapy to facilitate urinary stone passage: It is a well designed prospective RCT, which started in Leave a Reply Want to join the discussion? This was a study in Urology, a RCT, well designed, not particularly powerful pts and its conclusions were not supportive.

The Use of Alpha-Blockers for the Treatment of Nephrolithiasis

Patients receiving tamsulosin reported fewer instances of colic. July 9, at 5: Patients were followed for 6 weeks. Guidelines for medical expulsive therapy for urinary stones may need to be revised.

This could potentially reduce ED revisits, reduce the number of invasive procedures and make happy patients.

Tamsulosin treatment increases clinical success rate of single nepholithiasis shock wave lithotripsy of renal stones. At the conclusion of the study, patients filled out a EuroQuol questionnaire to evaluate quality nephrolithiawis life, and tamsulosin was shown to have significantly improved quality of life variables such as mobility, capacity to perform usual activities, pain and discomfort, and anxiety. Finally, the mean times to passage for the control group, and the groups receiving tamsulosin, terazosin, and doxazosin were Both meta analysis had positive findings in favor of the use of Tamsulosin.


However, the results are suspect. Oral diclofenac in the prophylactic treatment of recurrent renal colic. EM – Emergency Medicine Blog says: Mean stone size was significantly greater in the group receiving tamsulosin, 6.

Where does this leave us? Recent advances in endoscopic stone management have allowed kidney stones to be treated using minimally invasive techniques, which have increased success rates and decreased treatment-related morbidity.

Arch Intern Med ; The most important factors in predicting the likelihood of spontaneous stone passage are stone location and stone size. I question is applicability to stones between 4 and 10mm.

Tamsulosin Ineffective for Small Ureteral Stones

That brings us to the additional studies pointed out by your group. The Emer Med paper bundled more poor quality trials.

The pathophysiologic basis for this treatment is that alpha antagonists inhibit contraction of ureteral muscles responsible for ureterospasm allowing for an increased rate of stone glomax. Patients with distal ureteral stones given tamsulosin reported decreased pain using a visual analogue scale VAS. This review concluded that the results.

They may also reduce the urinary symptoms and pain associated with double-J ureteral stents. Nephropithiasis P and Hollingsworth JM. Distal ureteric stones and tamsulosin: The stone passage rates were determined by patient report and by imaging with radiography and renal ultrasound.