Bisphenol A (BPA)—an endocrine disruptor xenoestrogen—is widely spread in the environment. Lycopene (LYC) is an antioxidant. Background: The exact role of lycopene has not been studied in the past for its hepatoprotective effects. Hence it was decided to explore its anti-oxidant and. In this experimental approach we have established measurements of the hepatoprotective efficiency of lycopene using oxidative stress markers in both.

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These results were in agreement with Kurcer et al. China Peer-review report classification Grade A Excellent: Institutional review board statement: The sections were then incubated with 0.

Acetaminophen-induced acute liver failure: Meanwhile liver sections from the model group showed full fat vacuoles in lobule cells, infiltration of inflammatory cells, cell swelling and lipid degeneration in the central region of the lobules Figure 2BII.

Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants. An interest has been aroused in utilizing natural products isolated from plants against chemical compounds generating tissue damage [ 16 ].

Animals were fasted for 12 h before sampling of material.

The Journal of International Medical Research. It has the powerful antioxidant activity within carotenoids and is hepatoprotechive effective free radical scavenger. The liver tissue of rats in the control and LYC groups showed normal hepatocytes with normal arrangement of hepatic cords around the central veins Figures 1 a and 1 b.


Protective effect of Zhuyeqing liquor, a Chinese traditional health liquor, on acute alcohol-induced liver injury in mice.

These results were in harmony with those obtained by Kabuto et al.

Oxidative Medicine and Cellular Longevity

In addition, the histopathological changes from microscopy observation correlated with the examination of liver function. Hai X guaranteed the entire study; Jiang W carried out the whole experiment; Guo MH participated in the design of the study, performed the statistical analysis, and drafted the manuscript; Guo MH and Lycoene X edited and reviewed the manuscript; all authors read and approved the final manuscript.

The model group was continued on the HFD for 6 wk as before, and the Ly groups were administered orally and continued on the HFD for 6 wk as before. Virgin olive oil VOO and argan oil AO contain a wide variety of phytochemicals which are considered as a functional foods.

Hepatoprotective Effect of Olive and Argan Oils Supplemented with Tomato Lycopene in Wistar Rats

The imbalance between the free radical production and elimination leads to oxidative stress which can cause hepatic damage [ 3 ]. Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity.

Design and validation of a histological hepatoprorective system for nonalcoholic fatty liver disease. Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats.

Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

Antioxidant activities of carotenes and xanthophylls. It can immigrate into food or water on heating [ 5 ]. Moreover, administration of BPA disrupted hepatic integrity and functions where liver is considered the main organ involved in plasma protein biosynthesis [ 50 ]; thus, serum TP and albumin were declined.


Gastroenterology and hepatology Country of origin: Finally, LYC credited to have a noticeable protective effect versus BPA provoked oxidative injury and apoptosis of the liver tissue.

Gong ZM L- Editor: Meanwhile, LYC administration reduced the cytotoxic effects of BPA on hepatic tissue, through improving the liver function biomarkers and oxidant-antioxidant state as well as DNA damage around the control values.

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Appaji Rao, and K. All slides were lightly counterstained with hematoxylin for 30 seconds prior to dehydration and mounting [ 34 ]. Rats were randomly allotted to four experimental groups, seven rats each. Furthermore, the Mediterranean dietary pattern, which includes proportionally high consumption of vegetables and fruits with Ly, has shown notable hepatoprotectvie for NAFLD patients[ 2728 ].

Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

B Grade C Good: View at Google Scholar M. After acclimatization for 1 wk, 65 Wistar male rats were randomized into 2 groups. Mol Nutr Food Res.